Decrease of Cardiac Parkin Protein in Obese Mice

Frontiers in Cardiovascular Medicine

article

Amandine Thomas¹  Stefanie Marek-Iannucci¹  Kyle C. Tucker¹  Allen M. Andres¹  Roberta A. Gottlieb¹ 

[1] Cedars-Sinai Medical Center, Smidt Heart Institute

关键词: mitophagy;    Parkin;    obesity;    ischemia/reperfusion;    myocardium;    mitochondria;   

DOI  :  10.3389/fcvm.2019.00191

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Mitophagy plays a major role in heart physiology. Impairment of Parkin-dependent mitophagy in heart is known to be deleterious. Obesity is a known cardiovascular risk factor. Impaired autophagy has been reported in models of obesity or hyperlipidemia/hypercholesterolemia; however less is known regarding obesity and mitophagy. The aim of this study was to evaluate the regulation of Parkin expression in hearts of mice fed a high fat diet. Interestingly, we found a significant decrease in Parkin protein in hearts of HFD mice compared those fed a low-fat diet. This was associated with mitochondrial dysfunction in the context of ischemia/reperfusion (I/R). This downregulation was not associated with a decrease in Parkin mRNA expression. We did not detect any change in the degradation rate of Parkin and only a slight decrease in its translation. The reduction of Parkin protein abundance in HFD hearts remains a mystery and will need further studies. However, Parkin depletion in the setting of obesity may contribute to cardiovascular risk.

【 授权许可】

CC BY