Editorial: Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Frontiers in Cardiovascular Medicine

article

Thomas Pulinilkunnil¹  Petra Kienesberger¹  Jeevan Nagendran² 

[1] Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University;Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta

关键词: energy metabolism;    ATP;    cardiomyocyte;    heart failure;    fatty acid;   

DOI  :  10.3389/fcvm.2019.00097

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Energy metabolism is a process that is central to cardiac health and disease. High ATP turnover in the myocardium is required to maintain contractile function. ATP generation within the mitochondria involves oxidative decarboxylation of fatty acids, pyruvate, and the Krebs cycle to generate reducing equivalents for the oxidative phosphorylation of ADP in the electron transport chain. In the healthy adult heart, the majority of ATP is generated through the oxidation of fatty acids, and a tight balance between the utilization of fatty acids and other energy substrates is maintained (1). In metabolic heart disease myocardial ATP synthesis rate and free energy of ATP hydrolysis are decreased while ATP concentration is preserved (2). Metabolic remodeling and the decline of cardiac ATP production precede structural remodeling of the stressed heart and result from progressive maladaptation in substrate use and mitochondrial biogenesis and function (3, 4). Disrupted energy flux within the myocyte is recognized as a hallmark of cardiac failure (5). Metabolic remodeling not only disrupts cardiac energetics but also induces changes in cellular processes such as growth, redox homeostasis, and autophagy (6). Maladaptive changes in nutrient uptake, oxidation, and storage can lead to reduced energetic efficiency, ATP starvation, and ultimately cardiac dysfunction. This Research Topic is dedicated to articles (1) highlighting novel mechanisms that influence myocardial energy metabolism, (2) illustrating the role of cardiac metabolic pathways in health and disease, and (3) exploring translational avenues to target cardiac metabolism for the treatment of cardio-metabolic disorders.

【 授权许可】

CC BY