The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT

Frontiers in Pediatrics

article

Shahrzad Bakhtiar¹  Bella Shadur²  Polina Stepensky² 

[1] Division for Pediatric Stem Cell Transplantation and Immunology, University Hospital Frankfurt;Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah Medical Center;Department of Immunology, Garvan Institute of Medical Research;Graduate Research School, University of New South Wales

关键词: neutrophils;    neutropenia;    leukemia;    granulocyte colony-stimulating factor;    hematopoietic stem cell transplantation;   

DOI  :  10.3389/fped.2019.00436

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplantation is the only curative treatment for most patients with these diseases. In this review, we provide a detailed update on indications and outcomes of alloHSCT for congenital neutrophil disorders, based on data from the available literature.

【 授权许可】

CC BY