Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management

Frontiers in Pediatrics

article

Saima Aslam¹  Tammy Strickland¹  Eleanor J. Molloy¹ 

[1] National Maternity Hospital;UCD School of Medicine & Medical Sciences, University College Dublin;Trinity College Translational Medicine Institute, Trinity College Dublin, National Children's Hospital;Coombe Women's and Infant's University Hospital;Our Lady's Children's Hospital

关键词: neonatal encephalopthy;    etiology;    antenatal;    perinatal;    targeted adjunctive therapies;   

DOI  :  10.3389/fped.2019.00142

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities, thrombophilia, coagulation defects, and metabolic disorders all have been implicated in the pathogenesis of NE. At present, therapeutic hypothermia is the only treatment available, regardless of etiology. Recognizing the etiology of NE involved can also guide investigations such as metabolic and sepsis workups to ensure optimal management. Understanding the etiology of NE may allow the development of targeted adjunctive therapies related to the underlying mechanism and develop preventative strategies.

【 授权许可】

CC BY