Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success

Frontiers in Pediatrics

article

Maya Horst¹  Daniel Eberli²  Rita Gobet¹  Souzan Salemi² 

[1] Laboratory for Urologic Tissue Engineering and Stem Cell Therapy, Department of Urology, University Hospital;Division of Pediatric Urology, Department of Pediatric Surgery, University Children‘s Hospital

关键词: myelomeningocele;    neurogenic bladder;    bladder augmentation;    tissue engineering;    stem cells;    pediatric;   

DOI  :  10.3389/fped.2019.00091

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Several congenital disorders can cause end stage bladder disease and possibly renal damage in children. The current gold standard therapy is enterocystoplasty, a bladder augmentation using an intestinal segment. However, the use of bowel tissue is associated with numerous complications such as metabolic disturbance, stone formation, urine leakage, chronic infections, and malignancy. Urinary diversions using engineered bladder tissue would obviate the need for bowel for bladder reconstruction. Despite impressive progress in the field of bladder tissue engineering over the past decades, the successful transfer of the approach into clinical routine still represents a major challenge. In this review, we discuss major achievements and challenges in bladder tissue regeneration with a focus on different strategies to overcome the obstacles and to meet the need for living functional tissue replacements with a good growth potential and a long life span matching the pediatric population.

【 授权许可】

CC BY