Oxidative Stress and Bronchopulmonary Dysplasia: Evidences From Microbiomics, Metabolomics, and Proteomics

Frontiers in Pediatrics

article

Letizia Capasso¹  Giovanni Vento²  Cristina Loddo³  Chiara Tirone²  Federica Iavarone⁴  Francesco Raimondi¹  Carlo Dani⁵  Vassilios Fanos³ 

[1] Section of Pediatrics, Department of Translational Sciences, University of Naples Federico II;Division of Neonatology, Department of Woman and Child Health, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore;Neonatal Intensive Care Unit, Neonatal Pathology and Neonatal Section, Azienda Ospedaliero-Universitaria Cagliari and University of Cagliari;Institute of Biochemistry, Università Cattolica del Sacro Cuore;University Hospital Careggi

关键词: bronchopulmonary dysplasia;    oxidative stress;    newborn;    preterm;    microbiomics;    metabolomics;    proteomics;   

DOI  :  10.3389/fped.2019.00030

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Bronchopulmonary dysplasia is a major issue affecting morbidity and mortality of surviving premature babies. Preterm newborns are particularly susceptible to oxidative stress and infants with bronchopulmonary dysplasia have a typical oxidation pattern in the early stages of this disease, suggesting the important role of oxidative stress in its pathogenesis. Bronchopulmonary dysplasia is a complex disease where knowledge advances as new investigative tools become available. The explosion of the “omics” disciplines has recently affected BPD research. This review focuses on the new evidence coming from microbiomics, metabolomics and proteomics in relation to oxidative stress and pathogenesis of bronchopulmonary dysplasia. Since the pathogenesis is not yet completely understood, information gained in this regard would be important for planning an efficacious prevention and treatment strategy for the future.

【 授权许可】

CC BY