Clinical Characteristics and Outcomes of Pediatric Cerebral Venous Sinus Thrombosis: An Analysis of 30 Cases in China

Frontiers in Pediatrics

article

Xin-Hua Wang¹  Lin-Mei Zhang¹  Yi-Ming Chai¹  Ji Wang¹  Li-Fei Yu¹  Shui-Zhen Zhou¹ 

[1] Department of Neurology, Children's Hospital of Fudan University

关键词: stroke;    cerebral venous sinus thrombosis;    CVST;    child;    retrospective studies;   

DOI  :  10.3389/fped.2019.00364

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Cerebral venous sinus thrombosis (CVST) in children is rare in a clinical setting. The aim of this study was to summarize the etiological, clinical, and imaging characteristics of CVST in children. Methods: We retrospectively analyzed the data of 30 patients with a diagnosis of CVST who were admitted to Children's Hospital of Fudan University from 2008 to 2018. The medical records, including clinical manifestations, laboratory data, neurological findings, treatment, and short-term prognosis were analyzed. Results: Etiologically, the causes of CVST were infection (7/30), tumor (3/30), nephritis or nephrotic syndrome (8/30), traumatic brain injury (1/30), and undefined disease (11/30). All 30 cases were diagnosed with CVST after a neuroimaging examination using brain magnetic resonance imaging (MRI) combined with magnetic angiography venography (MRV). With regard to short-term prognosis, all the patients were treated with anticoagulants, after which 26 cases improved. Conclusions: CVST patients do not typically present with specific clinical manifestations, which leads to a high rate of misdiagnosis and delayed therapy. Increased consideration and prompt MRV checkup plays a key role in achieving an accurate diagnosis. Overall, anticoagulation is a safe and effective treatment for CVST.

【 授权许可】

CC BY