Sex Differences Between Female and Male Newborn Piglets During Asphyxia, Resuscitation, and Recovery

Frontiers in Pediatrics

article

Ramin P. La Garde¹  Po-Yin Cheung³  Maryna Yaskina³  Tze-Fun Lee²  Megan O'Reilly²  Georg M. Schmölzer² 

[1] Medical University of Vienna;Neonatal Research Unit, Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital;Department of Pediatrics, University of Alberta

关键词: infants;    newborn;    neonatal resuscitation;    chest compressions;    asphyxia;    sex differences;   

DOI  :  10.3389/fped.2019.00290

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Male and female newborns have differences in their fetal development, fetal-to-neonatal transition, and postnatal morbidity. However, the cardiovascular fetal-to-neonatal adaption is similar between sexes. No study has examined sex differences in newborns during hypoxia, asphyxia, cardio-pulmonary resuscitation, or post-resuscitation recovery. Methods: Secondary analysis (two previous publications and two studies currently under peer-review) of 110 term newborn mixed breed piglets (1–3 days of age, weighing 2.0 ± 0.2 kg), which were exposed to 30 min normocapnic hypoxia followed by asphyxia until asystole, which was achieved by disconnecting the ventilator and clamping the endotracheal tube. This was followed by cardio-pulmonary resuscitation. For the analysis piglets were divided into female and male groups. Cardiac function, carotid blood flow, and cerebral and renal oxygenation were continuously recorded throughout the experiment. Results: A total of 35/41 (85%) female and 54/69 (78%) male piglets resuscitated achieved ROSC ( p = 0.881). The median (IQR) time to achieve return of spontaneous circulation in females and males was 111 (80–228) s and 106 (80–206) s ( p = 0.875), respectively. The 4-h survival rate was similar between females and males with 28/35 (80%) and 49/54 (91%) piglets surviving ( p = 0.241), respectively. Conclusions: No difference between female and male newborn piglets was observed during hypoxia, asphyxia, resuscitation, and post-resuscitation recovery.

【 授权许可】

CC BY