Blood Pressure, Heart Rate Variability, and Adiposity in Caribbean Pre-pubertal Children

Frontiers in Pediatrics

article

Morgane Grandemange¹  Florence Rouget²  Nathalie Costet²  Matthieu Doyen³  Christine Monfort²  Léah Michineau²  Marie-Béatrice Saade¹  Luc Multigner²  Sylvaine Cordier²  Patrick Pladys⁴ 

[1] CHU Rennes, Endocrinologie-Diabétologie Pédiatrique;Irset (Institut de Recherche en Santé;Univ Rennes, Inserm, LTSI - UMR;Univ Rennes, CHU Rennes, Inserm, LTSI - UMR

关键词: blood pressure;    heart rate variability (HRV);    adiposity;    children;    pre pubertal;    BMI;    fat mass;    systolic blood pressure;   

DOI  :  10.3389/fped.2019.00269

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Childhood obesity prevalence has increased over the last 30 years. The Heart Rate Variability (HRV) studies performed in adults suggest a possible relation between abnormal autonomic regulation and hypertension in the situation of overweight or obesity. Objective: The aims of this study were to explore the early relationships between adiposity and blood pressure and HRV in pre-pubertal children. Methods: Data were collected during the medical examination of the follow-up at 7 years of the TIMOUN mother-child cohort in Guadeloupe. Body Mass Index z-score (zBMI), sum of tricipital and subscapular skinfold thickness, percentage of fat mass, and Waist-to-Height Ratio were measured. A global corpulence score was computed using a Principal Component Analysis (PCA). Systolic Blood Pressure (SBP) and HRV parameters (cardiac holter monitoring) were collected under 2 conditions (calm and tachycardial period). Relations between HRV, SBP, each adiposity indicator and the corpulence score were studied with restricted cubic splines models, and linear regression models. The age at adiposity rebound (AR) was estimated from the individual growth curves. Results: 575 children were included in the SBP study (mean age: 7.7 years, from 85 to 99 months). SBP was linearly correlated with the corpulence score and the zBMI. An increase of 1 in the zBMI was associated with an increase of 2.3 (±0.28) mmHg in SBP. The effect-size of zBMI on SBP was higher in children with early age at AR. Compared to children with normal BMI, children with a zBMI 2SD, we observed a global increase in all HRV parameters (under tachycardial conditions), particularly the LF [β = 0.43 (±0.18)]. Conclusion: In pre-pubertal period a positive correlation between adiposity excess and SBP was observed with significant changes of HRV in boys, arguing for an early abnormal autonomic regulation and for early preventive intervention in the infancy period, particularly in case of overweight or obesity. Thinness was associated with a reduction in almost all the HRV parameters studied, when compared to normal corpulence, suggesting a decrease in autonomic influence.

【 授权许可】

CC BY