Central Venous Access Devices (CVAD) in Pediatric Oncology Patients—A Single-Center Retrospective Study Over More Than 9 Years

Frontiers in Pediatrics

article

Olaf Beck¹  Oliver Muensterer¹  Sarah Hofmann¹  Heidi Rossmann²  Alicia Poplawski³  Jörg Faber¹  Jan Gödeke¹ 

[1] Children's Hospital, University Medical Center of the Johannes Gutenberg University Mainz;Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University Mainz;Institute of Medical Biostatistics, University Medical Center of the Johannes Gutenberg University Mainz

关键词: catheter-related complications;    children;    vascular access devices;    cancer;    catheter-related infections;    support care;   

DOI  :  10.3389/fped.2019.00260

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Central venous access devices (CVAD) provide important benefits in the management of oncological pediatric patients. However, these catheters are responsible for severe complications. Methods: In this context, we aimed to analyze all patients receiving a CVAD in the Department of Pediatric Hematology and Oncology of the University hospital of Mainz over a period of 9 years, focused on CVAD related complications. Data on demographics, as well as intraoperative and postoperative complications were extracted. Results: A total of 296 patients with a mean age 93.2 ± 62.4 months were analyzed. The majority suffered from leukemia ( n = 91, 30.7%), lymphomas ( n = 50, 16.9%), and brain tumors ( n = 48, 16.2%). In 63 (21.3) patients, complications were observed. No death caused by complications of CVADs was found in our series. Catheter-related blood stream infections (BSI) (7.4%) were most prevalent, followed by dislodgements (5.4%), occlusions (2.7%), thrombosis (2.4%), and catheter leakage (2.4%). Insertion site infections were observed in three patients (1.0%). Fifty-nine percent of all patients with catheter-related BSI suffered from Leukemia. In patients with Catheter-related BSIs we detected the condition leukemia as the underlying disease as a risk factor compared to solid tumors as the underlying disease. Overall, totally implanted devices (ports) have a lower complication rate than tunneled catheter. Conclusion: Implantation of CVADs seems to be safe and reliable in this large pediatric patient cohort. Even if complications occur in the long-term management of CVADs, they can be treated successfully and long-term catheter survival rates are excellent.

【 授权许可】

CC BY