Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study

Frontiers in Pediatrics

article

Monalisa Patel¹  Dibyendu Mukherjee²  Sina Farsiu³  Breda Munoz⁴  Arlin B. Blood¹  Christopher G. Wilson¹  Jennifer B. Griffin⁷ 

[1] Department of Pediatrics, Loma Linda University, United States;Department of Biomedical Engineering, Duke University, United States;Department of Ophthalmology, Duke University Medical Center, United States;Applied Public Health Research Center, Research Triangle Park, United States;Lawrence D. Longo Center for Perinatal Biology, Loma Linda University School of Medicine, United States;Department of Ophthalmology, Loma Linda University, United States;Center for Global Health, Research Triangle Park, United States

关键词: anterior lens capsule;    lens vasculature;    image analysis;    preterm;    gestational age;    neonatal;    smartphone ophthalmoscope;   

DOI  :  10.3389/fped.2019.00043

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction: Anterior lens capsule vascularity (ALCV) is resorbed in the developing fetus from 27 to 35 weeks gestation. In this pilot study, we evaluated the feasibility and validity of combining smartphone ophthalmoscope videos of ALCV and image analysis for gestational age estimation. Methods: ALCV videos were captured longitudinally in preterm neonates from delivery using a PanOptic® Ophthalmoscope with an iExaminer ® adapter (Welch-Allyn). ALCV video frames were manually selected and quantified using semi-automatic image analysis. A predictive model based on ALCV features was compared to gold-standard ultrasound gestational age estimates. Results: A total of 64 image-capture sessions were carried out in 24 neonates. Ultrasound-estimated gestational age and ALCV-predicted gestational age estimates indicate that the two methods are similar ( r = 0.78, p < 0.0001). ALCV estimates of gestational age were within 0.11 ± 1.3 weeks of ultrasound estimates. In the final model, gestational age was predicted within ± 1 week for 54% and within ± 2 weeks for 86% of the measures. Conclusions: This novel application of smartphone ophthalmoscopy and ALCV image analysis may provide a safe, accurate and non-invasive technology to estimate postnatal gestational age, especially in low income countries where gestational age may not be known at birth.

【 授权许可】

CC BY