COVID-19 Disease in Infants Less Than 90 Days: Case Series

Frontiers in Pediatrics

article

Lana A. Shaiba¹  Fahad Almughaileth³  Nasser Alyousef²  Prakesh S. Shah⁴  Khalid Altirkawi¹  Adnan Hadid¹  Sara Alsubaie¹  Omar Alharbi¹  Hamad Alkhalaf⁸  Musaed Alharbi⁸  Nourah Alruqaie^1,10  Omar Alzomor³ 

[1] Pediatric Department, College of Medicine, King Saud University;Neonatal Intensive Care Unit, King Saud University Medical City;Pediatric Infectious Diseases Department, Children Hospital;Department of Pediatrics, Mount Sinai Hospital;Department of Pediatrics, Toronto University;Maternal-Infant Care Research Centre, Mount Sinai Hospital;Pediatric Infectious Diseases Unit, King Saud University Medical City;Department of Pediatrics, King Saud Bin Abdulaziz University for Health Sciences;King Abdullah International Medical Research Center;Department of Pediatrics, King Abdullah Specialist Children's Hospital

关键词: COVID-19;    infants;    MIS-C;    SARS-CoV-2;    90 days;   

DOI  :  10.3389/fped.2021.674899

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The objective of this study is to describe the clinical presentations, radiological and laboratory findings, and outcomes of COVID-19 disease in infants ≤ 90 days of age at presentation. We conducted a retrospective study of infants in this age group who were found to be SARS-CoV-2 positive. Asymptomatic infants who were identified through routine testing following delivery to COVID-19-positive mothers were excluded. We classified infants according to their presentation: asymptomatic, mildly symptomatic, moderately symptomatic, and severely/critically symptomatic. A total of 36 infants were included. Of them, two were asymptomatic and four had severe/critical presentation. Of the severely symptomatic infants, two were considered as multisystem inflammatory syndrome in children (MIS-C) and there was one death. One infant in the severe symptomatic group presented with cardiac failure, with the possibility of congenital infection. Another infant presented with cardiogenic shock. None of these infants received antiviral medication. The study found that infants ≤ 90 days can present with a severe form of COVID-19 disease. Multisystem inflammatory syndrome in children, although rarely reported in infants, is a possible complication of COVID-19 disease and can be associated with significant morbidity and mortality.

【 授权许可】

CC BY