Early Postnatal Metabolic Profile in Neonates With Different Birth Weight Status: A Pilot Study

Frontiers in Pediatrics

article

Serdar Beken¹  Ezgi Bulbul¹  Didem Kaya¹  Melis Karabay¹  Zeynep Alize Ay¹  Gulten Zeynep Eksi¹  Fehime Benli Aksungar²  Ayse Korkmaz¹  Mustafa Serteser³  Saygin Abali⁴  Neslihan Yildirim Saral²  Bengisu Guner⁵  Taha Dinc¹  Eda Albayrak¹  Melike Ersoy⁶  Meltem Kilercik³  Muge Halici¹ 

[1] Department of Pediatrics, Section of Neonatology, School of Medicine, Acibadem Mehmet Ali Aydinlar University;Department of Metabolism, Acibadem Labmed Clinical Laboratories;Department of Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydinlar University;Department of Pediatrics, Section of Pediatric Endocrinology, School of Medicine, Acibadem Mehmet Ali Aydinlar University;Department of Pediatrics, School of Medicine, Acibadem Mehmet Ali Aydinlar University;Department of Pediatrics, Bakirkoy Dr Sadi Konuk Training and Research Hospital, University of Health Sciences

关键词: small for gestation age;    large for gestational age;    carnitine;    metabolomics (OMICS);    tandem MS;   

DOI  :  10.3389/fped.2021.646860

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this study, the relationship between intrauterine growth status and early metabolomics profile was evaluated. Materials and Methods: A single-center retrospective cohort study was conducted. Three hundred and sixty-one newborn infants were enrolled into the study, and they were grouped according to their birth weight percentile as small for gestational age (SGA, n = 69), appropriate for gestational age (AGA, n = 168), and large for gestational age (LGA, n = 124) infants. In all infants, amino acid and carnitine/acylcarnitine profiles with liquid chromatography-tandem mass spectrometry (LC-MS/MS) were recorded and compared between groups. Results: LGA infants had higher levels of glutamic acid and lower levels of ornithine, alanine, and glycine ( p < 0.05) when compared with AGA infants. SGA infants had higher levels of alanine and glycine levels when compared with AGA and LGA infants. Total carnitine, C0, C2, C4, C5, C10:1, C18:1, C18:2, C14-OH, and C18:2-OH levels were significantly higher and C3 and C6-DC levels were lower in SGA infants ( p < 0.05). LGA infants had higher C3 and C5:1 levels and lower C18:2 and C16:1-OH levels ( p < 0.05). There were positive correlations between free carnitine and phenylalanine, arginine, methionine, alanine, and glycine levels ( p < 0.05). Also, a positive correlation between ponderal index and C3, C5-DC, C14, and C14:1 and a negative correlation between ponderal index and ornithine, alanine, glycine, C16:1-OH, and C18:2 were shown. Conclusion: We demonstrated differences in metabolomics possibly reflecting the energy metabolism in newborn infants with intrauterine growth problems in the early postnatal period. These differences might be the footprints of metabolic disturbances in future adulthood.

【 授权许可】

CC BY