Comparison of PICU Cost and Severity-Adjusted Cost Between Patients With SIRS-Defined Sepsis and Those With Age-Adapted SOFA-Defined Sepsis

Frontiers in Pediatrics

article

Xuepeng Zhang¹  Kaibo Sun³  Guoyan Lu⁴  Liwei Feng¹  Siyuan Chen²  Yi Ji¹ 

[1] Department of Pediatric Surgery, West China Hospital of Sichuan University;Department of Critical Care Medicine, West China Hospital of Sichuan University;West China School of Medicine, Sichuan University;Pediatric Intensive Care Unit, West China Second University Hospital, Sichuan University

关键词: pediatric;    sepsis;    illness severity;    critical care;    cost;   

DOI  :  10.3389/fped.2021.628918

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: The 2005 International Pediatric Sepsis Consensus definition is considered to lack specificity and may lead to the admission of low-risk patients to the pediatric intensive care unit (PICU). The aim of this study was to compare the PICU cost and the severity-adjusted cost between patients with sepsis defined by the 2005 International Pediatric Sepsis Consensus and those diagnosed using the age-adapted Sepsis-3 criteria. Methods: Septic children identified by the 2005 Consensus were screened for enrollment. The enrolled children were stratified into two subgroups using the age-adapted Sepsis 3.0 definition. A comparison was made between the subgroups of sepsis 3.0-defined children and non-sepsis 3.0-defined septic children. The Severity Adjusted ICU Cost (SAIC) was used to evaluate the case-mixed severity-adjusted costs of the study population. Coefficients in linear regression analyses in subgroups were calculated for presenting variation of PICU costs for every unit change of PRISM score. Results: A total of 397 children were enrolled. The PICU length of stay was longer in the sepsis 3.0 group than in the non-sepsis 3.0 group [median (IQR), 9.0 (5.0, 15.0) vs. 6.0 (3.0, 9.0); P < 0.001]. Pediatric risk of mortality (PRISM) scores and mortality were significantly higher in sepsis 3.0-defined septic patients. The total costs and daily costs in the PICU were both significantly lower in the non-sepsis 3.0 group ( P < 0.001). The severity-adjusted ICU cost in the non-sepsis 3.0 group was lower than that in the sepsis 3.0 group [median (IQR), 7,125 (3,588, 11,134) vs. 9,364 (5,680, 15,876); P = 0.001]. There was no significant difference among the regression coefficients. Conclusions: The 2005 International Pediatric Sepsis Consensus definition does not lead to more PICU costs after considering illness severity. Clinical Trial Registration:www.ClinicalTrials.gov , identifier: {"type":"clinical-trial","attrs":{"text":"NCT03598127","term_id":"NCT03598127"}} NCT03598127 .

【 授权许可】

CC BY