Possible Hepatoprotective Effect of Tocotrienol-Rich Fraction Vitamin E in Non-alcoholic Fatty Liver Disease in Obese Children and Adolescents

Frontiers in Pediatrics

article

Farah D.R. Al-Baiaty¹  Aziana Ismail¹  Zarina Abdul Latiff²  Khairul Najmi Muhammad Nawawi³  Raja Affendi Raja Ali³  Norfilza Mohd Mokhtar¹ 

[1] Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia;Department of Pediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia;Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia;GUT Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia

关键词: non-alcoholic fatty liver disease;    vitamin E;    tocotrienol;    obesity;    children;    overweight;   

DOI  :  10.3389/fped.2021.667247

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Obesity has become a worldwide health concern among the pediatric population. The prevalence of non-alcoholic fatty liver disease (NAFLD) is growing rapidly, alongside the high prevalence of obesity. NAFLD refers to a multifactorial disorder that includes simple steatosis to non-alcoholic steatohepatitis (NASH) with or devoid of fibrosis. NAFLD is regarded as a systemic disorder that influences glucose, lipid, and energy metabolism with hepatic manifestations. A sedentary lifestyle and poor choice of food remain the major contributors to the disease. Prompt and timely diagnosis of NAFLD among overweight children is crucial to prevent the progression of the condition. Yet, there has been no approved pharmacological treatment for NAFLD in adults or children. As indicated by clinical evidence, lifestyle modification plays a vital role as a primary form of therapy for managing and treating NAFLD. Emphasis is on the significance of caloric restriction, particularly macronutrients (fats, carbohydrates, and proteins) in altering the disease consequences. A growing number of studies are now focusing on establishing a link between vitamins and NAFLD. Different types of vitamin supplements have been shown to be effective in treating NAFLD. In this review, we elaborate on the potential role of vitamin E with a high content of tocotrienol as a therapeutic alternative in treating NAFLD in obese children.

【 授权许可】

CC BY