Case Report: The Use of Intravenous SMOFlipid Infusion to Treat Severe Asparaginase-Induced Hypertriglyceridemia in Two Pediatric Acute Lymphoblastic Leukemia Patients

Frontiers in Pediatrics

article

Sie Chong Doris Lau¹  C-Khai Loh¹  Hamidah Alias¹ 

[1] Pediatric Hematology and Oncology Unit, Department of Pediatrics, UKM Medical Centre, Faculty of Medicine, The National University of Malaysia

关键词: acute lymphoblastic leukemia;    asparaginase;    hypertriglyceridemia;    omega-3;    SMOFlipid;    pediatric;    case report;   

DOI  :  10.3389/fped.2021.660627

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Asparaginase-induced hypertriglyceridemia can have a spectrum of clinical presentations, from being asymptomatic to having life-threatening thrombosis or hyperviscosity syndrome. At present, there is no recommendation on routine lipid monitoring during asparaginase-containing treatment phase, nor a standardized guideline on its management. Two cases are presented here to illustrate the effects of concurrent infection on asparaginase-induced hypertriglyceridemia in patients with high-risk ALL and the use of SMOFlipid infusion as a treatment option in an acute situation.

【 授权许可】

CC BY