Monitoring Fetal Electroencephalogram Intrapartum: A Systematic Literature Review

Frontiers in Pediatrics

article

Aude Castel¹  Yael S. Frank²  John Feltner³  Floyd B. Karp⁴  Catherine M. Albright²  Martin G. Frasch² 

[1] Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal;Department of Obstetrics and Gynecology, University of Washington, United States;Department of Pediatrics, University of Washington, United States;School of Pharmacy, University of Washington, United States;Center on Human Development and Disability, University of Washington, United States

关键词: EEG;    labor;    fetus;    neonates;    infant;    magnetoencephalogram;    electrocorticogram;   

DOI  :  10.3389/fped.2020.00584

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Studies about the feasibility of monitoring fetal electroencephalogram (fEEG) during labor began in the early 1940s. By the 1970s, clear diagnostic and prognostic benefits from intrapartum fEEG monitoring were reported, but until today, this monitoring technology has remained a curiosity. Objectives: Our goal was to review the studies reporting the use of fEEG including the insights from interpreting fEEG patterns in response to uterine contractions during labor. We also used the most relevant information gathered from clinical studies to provide recommendations for enrollment in the unique environment of a labor and delivery unit. Data Sources: PubMed. Eligibility Criteria: The search strategy was: (“fetus”[MeSH Terms] OR “fetus”[All Fields] OR “fetal”[All Fields]) AND (“electroencephalography”[MeSH Terms] OR “electroencephalography”[All Fields] OR “eeg”[All Fields]) AND (Clinical Trial[ptyp] AND “humans”[MeSH Terms]). Because the landscape of fEEG research has been international, we included studies in English, French, German, and Russian. Results: From 256 screened studies, 40 studies were ultimately included in the qualitative analysis. We summarize and report features of fEEG which clearly show its potential to act as a direct biomarker of fetal brain health during delivery, ancillary to fetal heart rate monitoring. However, clinical prospective studies are needed to further establish the utility of fEEG monitoring intrapartum. We identified clinical study designs likely to succeed in bringing this intrapartum monitoring modality to the bedside. Limitations: Despite 80 years of studies in clinical cohorts and animal models, the field of research on intrapartum fEEG is still nascent and shows great promise to augment the currently practiced electronic fetal monitoring. Prospero Number : CRD42020147474.

【 授权许可】

CC BY