期刊论文详细信息
Frontiers in Pediatrics | |
Overgrowth Syndromes—Evaluation, Diagnosis, and Management | |
article | |
Joshua Manor1  Seema R. Lalani1  | |
[1] Department of Molecular Genetics, Baylor College of Medicine, United States | |
关键词: overgrowth; Beckwith-Wiedemann; Simpson-Golabi-Behmel; Sotos; Weaver; Pten; PIK3CA; Proteus Syndrome; | |
DOI : 10.3389/fped.2020.574857 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
【 摘 要 】
Abnormally excessive growth results from perturbation of a complex interplay of genetic, epigenetic, and hormonal factors that orchestrate human growth. Overgrowth syndromes generally present with inherent health concerns and, in some instances, an increased risk of tumor predisposition that necessitate prompt diagnosis and appropriate referral. In this review, we introduce some of the more common overgrowth syndromes, along with their molecular mechanisms, diagnostics, and medical complications for improved recognition and management of patients affected with these disorders.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO202108180003629ZK.pdf | 1450KB | download |