Validation of an IGF1 Screening Method for Retinopathy of Pre-maturity

Frontiers in Pediatrics

article

Alejandro Pérez-Muñuzuri¹  Olalla López-Suárez¹  Natalia Mandiá-Rodríguez¹  Carolina López-Sanguos¹  María José Blanco-Teijeiro³  María Luz Couce¹ 

[1] Neonatology Unit, University Clinical Hospital of Santiago;Department of Forensic Sciences, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela;Retinal Unit, University Clinical Hospital of Santiago;Department of Ophthalmology, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela

关键词: retinopathy of pre-maturity;    pre-term;    IGF1;    screening;    validation;   

DOI  :  10.3389/fped.2020.615716

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Retinopathy of pre-maturity (ROP) is a retinal disease that causes arrest of vascularization of the retina and can result in retinal detachment and blindness. Current screening protocols may not be sufficiently accurate to identify all at-risk patients. The aim of this study is to validate a method for improved identification of newborns at risk of ROP. We conducted a prospective clinical trial of pre-term newborns <32 weeks of gestation and/or <1,500 g birth weight during a 6-year period in a tertiary care hospital. We applied our new method based on measurement of insulin-like growth factor 1 (IGF1) levels at 3 weeks of age and the presence of sepsis during the first 3 weeks of life. Our screening protocol allowed exclusion of 121 (79.1%) patients for whom American Academy of Pediatrics (AAP) guidelines recommended screening, had a negative predictive value of 100%, and correctly identified all patients with ROP. Following retrospective assessment of our data based on these findings, we propose further restriction of the current AAP indications for screening to <1,100 g and <28 weeks of gestation in order to improve diagnostic efficacy while ensuring optimal use of restriction of human and material resources.

【 授权许可】

CC BY