Fecal Calprotectin in Combination With Standard Blood Tests in the Diagnosis of Inflammatory Bowel Disease in Children

Frontiers in Pediatrics

article

Shaun S. C. Ho¹  Michael Ross¹  Jacqueline I. Keenan²  Andrew S. Day¹ 

[1] Department of Pediatrics, University of Otago;Department of Surgery, University of Otago

关键词: inflammatory bowel disease;    fecal calprotectin;    serum albumin;    platelet count;    pediatrics;    diagnosis;   

DOI  :  10.3389/fped.2020.609279

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction: Fecal calprotectin (FC) is a useful non-invasive screening test but elevated levels are not specific to inflammatory bowel disease (IBD). The study aimed to evaluate the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of FC alone or FC in combination with other standard blood tests in the diagnosis of IBD. Methods: Children aged 50 μg/g or elevated platelet count. Furthermore, PPVs in diagnosing IBD improved when FC at various thresholds was combined with either low albumin or high platelet count. Conclusion: Although FC alone is a useful screening test for IBD, a normal FC alone does not exclude IBD. Extending FC to include albumin or platelet count may improve sensitivity, specificity, PPV and NPV in diagnosing IBD. However, prospective studies are required to validate this conclusion.

【 授权许可】

CC BY