Childhood Obesity: Does it Have Any Effect on Young Arteries?

Frontiers in Pediatrics

article

Andrea Emese Jakab¹  Erzsébet Valéria Hidvégi²  Miklós Illyés²  Attila Cziráki²  Tibor Kalmár¹  Zoltán Maróti¹  Csaba Bereczki¹ 

[1] Department of Pediatrics, Albert Szent-Györgyi Health Center, University of Szeged;Heart Institute, UP Clinical Centre, University of Pécs

关键词: children and adolescents;    overweight;    obesity;    arterial stiffness;    pulse wave velocity;    augmentation index;    central blood pressure;   

DOI  :  10.3389/fped.2020.00389

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Prevalence of overweight (OW) and obesity (O) in children and adolescents has been increased in the past three decades. Increased arterial stiffness measuring by aortic pulse wave velocity (PWV ao ) might be detected in OW/O children and adolescents. The aim of our study was to compare the arterial function parameters (AFPs), such as PWV ao ; aortic augmentation index (Aix ao ); aortic systolic blood pressure (SBP ao ) and brachial systolic blood pressure (SBP brach ) measured simultaneously in O/OW patients and healthy subjects. In our study 6,816 subjects (3,668 boys) aged 3–18 years were recruited and categorized by their body mass index (BMI) into normal weight (N), OW and O groups regarding their age and sex. AFPs were measured by a non-invasive, occlusive-oscillometric device. 19.9% ( n = 1,356) of the population were OW/O, 911 (516 boys) were OW and 445 (272 boys) were O. After accounting for the effect of covariates, PWV ao did not differ significantly between N (5.9 ± 0.8 m/s) and OW patients (5.9 ± 0.8 m/s); and N (6.0 ± 0.7 m/s) and O patients (6.0 ± 0.8 m/s). Aix ao was significantly lower in OW (9.3 ± 7.4% vs. 7.6 ± 7.0%, p < 0.00001) and in O patients (9.7 ± 8.1% vs. 6.6 ± 7.2%, p < 0.00001) compared to controls. No significant difference was found regarding SBP ao values between controls and OW and O groups ( N = 110.7 ± 12.4 mmHg vs. OW = 110.3 ± 11.9 mmHg; N = 115.6 ± 14.0 mmHg vs. O = 114.3 ± 12.8 mmHg). According to our results we may conclude that the unchanged PWV ao in O/OW subjects might be due to the compensatory decrease in Aix ao , referring to enhanced vasodilatory status in the studied population.

【 授权许可】

CC BY