Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children

Frontiers in Pediatrics

article

Maria D. Ordóñez-Díaz¹  Juan L. Pérez-Navero²  Katherine Flores-Rojas³  Josune Olza-Meneses⁴  Maria C. Muñoz-Villanueva⁵  Concepción M. Aguilera-García⁴  Mercedes Gil-Campos³ 

[1] Department of Paediatrics, Maimónides Biomedical Research Institute, Reina Sofía University Hospital, University of Córdoba;Centre for Biomedical Research on Rare Diseases (CIBERER-ISCIII);Unit of Metabolism and Paediatric Research, Maimónides Biomedical Research Institute, Reina Sofia University Hospital, University of Córdoba;Laboratory 123, Department of Biochemistry and Molecular Biology II, Centre of Biomedical Research, Institute of Nutrition and Food Technology, University of Granada;Unit of Methodological Support to Research, Maimónides Biomedical Research Institute

关键词: prematurity;    extrauterine growth restriction;    inflammation;    cytokines;    metabolism;    hypertension;    programming;   

DOI  :  10.3389/fped.2020.00180

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Introduction: An adipose tissue programming mechanism could be implicated in the extrauterine growth restriction (EUGR) of very preterm infants with morbidity in the cardiometabolic status later in life, as has been reported in intrauterine growth restriction. The aim of this study was to assess whether children with a history of prematurity and EUGR, but also with an adequate growth, showed alterations in the metabolic and inflammatory status. Methods: This was a case–control study. A total of 88 prepubertal children with prematurity antecedents were selected: 38 with EUGR and 50 with an adequate growth pattern (PREM group). They were compared with 123 healthy children born at term. Anthropometry, metabolic parameters, blood pressure (BP), C-reactive protein, hepatocyte growth factor (HGF), interleukin-6 (IL-6), IL-8, monocyte chemotactic protein type 1 (MCP-1), neural growth factor, tumour necrosis factor-alpha (TNF-α) and plasminogen activator inhibitor type-1 were analysed at the prepubertal age. Results: EUGR children exhibited higher BP levels and a higher prevalence of hypertension (46%) compared with both PREM (10%) and control (2.5%) groups. Moreover, there was a positive relationship between BP levels and values for glucose, insulin and HOMA-IR only in children with a EUGR history. The EUGR group showed higher concentrations of most of the cytokines analysed, markedly higher TNF-α, HGF and MCP-1 levels compared with the other two groups. Conclusion: EUGR status leads to cardiometabolic changes and a low-grade inflammatory status in children with a history of prematurity, and that could be related with cardiovascular risk later in life.

【 授权许可】

CC BY