Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants

Frontiers in Pediatrics

article

Xiaoli Wang¹  Yuheng Zhang¹  Hua Mei¹  Caiyan An²  Chunzhi Liu¹  Yayu Zhang¹  Yanbo Zhang¹  Chun Xin¹ 

[1] Division of Neonatology, Department of Pediatric, The Affiliated Hospital of Inner Mongolia Medical University;Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University

关键词: respiratory distress syndrome (RDS);    pulmonary surfactant protein A1 (SP-A1);    gene polymorphism;    Mongolian very premature infants;    respiratory tract management;   

DOI  :  10.3389/fped.2020.00081

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Aim: To study the relationship between rs1059057 polymorphism of pulmonary surfactant protein A1 (SP-A1) and respiratory distress syndrome (RDS) in Mongolian very premature infants. Methods: Applying the strategy of case-control study, 120 Mongolian RDS very premature infants (58 males and 62 females) in the western part of Inner Mongolia were selected as the case group, and 120 subjects of non-RDS very premature infants (56 males and 64 females) with the same nationality, same sex and similar gestational age were used as the control group. The single nucleotide polymorphism (SNP) site rs1059057 of SP-A1 was genotyped using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP). Results: Two genotypes, A/G and A/A , were detected at the SP-A1 rs1059057 locus in the western part of Inner Mongolia. In the case group, the frequencies of two genotypes were 53 and 47%, and the frequencies of A allele and G allele were 73 and 27%, respectively. In the control group, the frequencies of the two genotypes were 42 and 58%, and the frequencies of A allele and G allele were 79 and 21%, respectively. There was no significant difference in the genotype frequency of SP-A1 (rs1059057) locus between the case group and the control group ( X 2 = 3.275, P > 0.05), and no significant difference in allele frequency between the case group and the control group ( X 2 = 2.255, P > 0.05). Conclusion: The genotypes and allele frequencies of SP-A1 (rs1059057) locus were not associated with the incidence of RDS in Mongolian very premature infants in western Inner Mongolia.

【 授权许可】

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