IPEX as a Consequence of Alternatively Spliced FOXP3

Frontiers in Pediatrics

article

Reiner K. Mailer¹ 

[1] Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf

关键词: Foxp3;    isoform;    alternative splicing;    IPEX;    CD4 + T cell;   

DOI  :  10.3389/fped.2020.594375

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The transcription factor FOXP3 controls the immunosuppressive program in CD4 + T cells that is crucial for systemic immune regulation. Mutations of the single X-chromosomal FOXP3 gene in male individuals cause the inherited autoimmune disease immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome. Insufficient gene expression and impaired function of mutant FOXP3 protein prevent the generation of anti-inflammatory regulatory T (Treg) cells and fail to inhibit autoreactive T cell responses. Diversification of FOXP3 functional properties is achieved through alternative splicing that leads to isoforms lacking exon 2 (FOXP3Δ2), exon 7 (FOXP3Δ7), or both (FOXP3Δ2Δ7) specifically in human CD4 + T cells. Several IPEX mutations targeting these exons or promoting their alternative splicing revealed that those truncated isoforms cannot compensate for the loss of the full-length isoform (FOXP3fl). In this review, IPEX mutations that change the FOXP3 isoform profile and the resulting consequences for the CD4 + T-cell phenotype are discussed.

【 授权许可】

CC BY