The Role of Vitamin D Deficiency in Children With Recurrent Wheezing—Clinical Significance

Frontiers in Pediatrics

article

Gavriela Feketea¹  Corina I. Bocsan³  Luminita Aurelia Stanciu⁴  Anca Dana Buzoianu³  Mihnea Tudor Zdrenghea¹ 

[1] Department of Hematology, “Iuliu Hatieganu” University of Medicine and Pharmacy;Department of Pediatrics, Pediatric Allergy Outpatient Clinic, “Karamandaneio” Children Hospital;Department of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy;Airways Disease Infection Section, National Heart and Lung Institute, Imperial College London, United Kingdom;Department of Hematology, Ion Chiricuta Oncology Institute

关键词: vitamin D;    25(OH)D;    vitamin D receptor (VDR);    recurrent wheezing;    asthma;    respiratory allergies;   

DOI  :  10.3389/fped.2020.00344

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Recurrent wheezing (RW) in infancy is one of the most frequent reasons for parents to consult health care providers and creates a significant global burden. Clinical course of RW is difficult to predict, also which infants will progress to asthma, since no valid biomarkers have been established. Identification of those infants with RW who are at risk of further recurrences and/or severe acute respiratory tract infection (ARTI) could help pediatricians to improve their therapeutic decisions. Increasing research interest is focused on the extra-skeletal actions of vitamin D (VD) and the clinical impact of VD insufficiency/deficiency. As VD deficiency could be a risk factor for causing RW in children, measurement of their serum level of 25-hydroxycholecalciferol [25(OH)D] is recommended. In the case of deficiency, VD administration is recommended in age-appropriate doses for at least 6 weeks, until achievement of normal blood 25(OH)D level, followed by supplementation as long as exposure to sun is inadequate. Higher doses of VD given in an attempt to prevent asthma development appear to be of no additional benefit. In children with severe ARTI, VD level is recommended to be assess.

【 授权许可】

CC BY