期刊论文详细信息
Frontiers in Pediatrics | |
Linear Growth in Pediatric Kidney Transplant Population | |
article | |
Mercedes Lopez-Gonzalez1  Marina Munoz1  Victor Perez-Beltran1  Alejandro Cruz1  Romy Gander2  Gema Ariceta1  | |
[1]Department of Pediatric Nephrology, University Hospital Vall d'Hebron | |
[2]Pediatric Urology and Renal Transplant Unit, Department of Pediatric Surgery, University Hospital Vall d'Hebron | |
[3]Department of Pediatrics, University Autonomous of Barcelona | |
关键词: growth; pediatric; kidney transplant; height; growth hormone; | |
DOI : 10.3389/fped.2020.569616 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
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【 摘 要 】
Introduction: Growth retardation is one of the main complications of chronic kidney disease (CKD) in children and induces a negative impact on quality of life. Materials and Methods: Retrospective analysis of all consecutive patients younger than 18 years old who received a first KT in our center between 2008 and 2018. Results: 95 first KT recipients, median age at KT of 7.83 years. At the time of KT, 65.52% of males and 54.05% females showed normal height. After transplantation, linear growth improved from −1.53 at transplant to −1.37 SDS height at the last visit. We detected a different linear growth pattern according to patient age at KT. Children younger than 3 years old exhibited the most significant growth retardation at baseline and the greatest linear growth over time (−2.29 vs. −1.82 SDS height), whereas catch-up was not observed in older patients. Multivariate analysis showed that use of corticosteroids was negatively related to SDS height at 1 year after transplantation and final SDS height only was positively associated with SDS height at KT. 44.2 and 22.1% patients received rhGH treatment before and after KT. 71.88% patients reached adulthood with normal final height. Conclusions: In our study, pediatric KT recipients exhibited a normal height in more than half of cases at KT and in more than two thirds at the final adult height. Only children younger than 6 years old presented a relevant growth catch-up after KT. Treatment with rhGH was used before and after KT with significant improvement in height.【 授权许可】
CC BY
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RO202108180002760ZK.pdf | 397KB | ![]() |