The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on “At-Risk” Individuals

Frontiers in Medicine

article

Laurence Duquenne¹  Rahaymin Chowdhury³  Kulveer Mankia¹  Paul Emery¹ 

[1] Leeds Biomedical Research Centre—NIHR, United Kingdom;Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, United Kingdom;Leeds Teaching Hospital Trust, United Kingdom

关键词: arthritis (including rheumatoid arthritis);    ultrasound;    at risk;    prediction;    ACPA;    anti-cyclic citrullinated peptide antibodies;   

DOI  :  10.3389/fmed.2020.587827

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

In individuals at-risk of developing inflammatory arthritis, the value of an ultrasound (US) scan assessment to predict progression has been demonstrated repeatedly. However, depending on recruitment criteria, these individuals may be at different stages in the arthritis development continuum, therefore representing a heterogeneous population. As a consequence, the predictive value of ultrasound results may differ between cohorts. As other reviews have focused on the challenges in population recruitment or have combined biomarkers predicting value according to one recruitment pathway, we wanted to focus on the sole use of ultrasound assessment and its variation according to population recruitment criteria. In this review, we discuss the use of ultrasound in the different at-risk populations across the inflammatory arthritis disease continuum. This review demonstrates that although some sub-population data is scarce, ultrasound is best predictive in three at-risk populations: those with a positive ACPA test in the context of non-specific MSK symptoms, those with clinically suspect arthralgia and those with palindromic rheumatism. We consider that ultrasound assessment will be a cornerstone in prediction risk modeling and prevention studies of the preclinical phases of IA in the future.

【 授权许可】

CC BY