Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD

Frontiers in Medicine

article

Xiaofan Jiang¹  Juan Zheng²  Shixiu Zhang¹  Baozhen Wang¹  Chaodong Wu⁴  Xin Guo¹ 

[1] Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University;Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology;Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders;Department of Nutrition, Texas A&M University, College Station, United States

关键词: circadian;    microbiota;    metabolic diseases;    NAFLD;    inflammation;    reprogramming;   

DOI  :  10.3389/fmed.2020.00361

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and progresses to non-steatohepatitis (NASH) when the liver displays overt inflammatory damage. Increasing evidence has implicated critical roles for dysbiosis and microbiota-host interactions in NAFLD pathophysiology. In particular, microbiota alter intestine absorption of nutrients and intestine permeability, whose dysregulation enhances the delivery of nutrients, endotoxin, and microbiota metabolites to the liver and exacerbates hepatic fat deposition and inflammation. While how altered composition of gut microbiota attributes to NAFLD remains to be elucidated, microbiota metabolites are shown to be involved in the regulation of hepatocyte fat metabolism and liver inflammatory responses. In addition, intestinal microbes and circadian coordinately adjust metabolic regulation in different stages of life. During aging, altered composition of gut microbiota, along with circadian clock dysregulation, appears to contribute to increased incidence and/or severity of NAFLD.

【 授权许可】

CC BY