Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study

Frontiers in Medicine

article

Rong Chen¹  Qing-tao Meng¹  Daqing Ma³  Yan-li Yu¹  Wei Li¹  Ya Liu⁴  Jing-xiao Lu²  Fangyue Chen⁵  Qin Zhou¹  Zhong-yuan Xia¹  Ling Gao⁶ 

[1] Department of Anesthesiology, Renmin Hospital of Wuhan University;Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University;Division Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, United Kingdom;Department of Gastroenterology, Renmin Hospital of Wuhan University;Department of General Medicine, Peterborough City Hospital, North West Anglia NHS Foundation Trust, United Kingdom;Department of Endocrinology and Metabolism, Renmin Hospital of Wuhan University

关键词: gastrointestinal symptoms;    COVID-19;    prognosis;    SARS-CoV-2 (COVID-19);    ARDS (acute respiratory distress syndrome);   

DOI  :  10.3389/fmed.2020.608259

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background and Aim: The global pandemic of COVID-19 has posed an enormous threat to the economy and people's lives across various countries. Patients with COVID-19 most commonly present with respiratory symptoms. However, gastrointestinal (GI) symptoms can also occur. We aimed to study the relationship between GI symptoms and disease prognosis in patients with COVID-19. Methods: In a single-center and retrospective cohort study, the outcomes in COVID-19 patients with or without GI symptoms were compared. The propensity score is a conditional probability of having a particular exposure (COVID-19 patients with GI symptoms vs. without GI symptoms) given a set of baseline measured covariates. Survival was estimated using the Kaplan-Meier method, and any differences in survival were evaluated with a stratified log-rank-test. To explore the GI symptoms associated with ARDS, non-invasive ventilator treatment, tracheal intubation, tracheotomy, and CRRT, univariable and multivariable COX regression models were used. Results: Among 1,113 eligible patients, 359 patients with GI symptoms and 718 without GI symptoms had similar propensity scores and were included in the analyses. Patients with GI symptoms, as compared with those without GI symptoms, were associated with a similar risk of death, but with higher risks of ARDS, non-invasive mechanical ventilation in COVID-19 patients, respectively. Conclusions: The presence of GI symptoms was associated with a high risk of ARDS, non-invasive mechanical ventilation and tracheal intubation in patients with COVID-19 but not mortality.

【 授权许可】

CC BY