Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019

Frontiers in Medicine

article

R. Tedjo Sasmono¹  Frilasita A. Yudhaputri¹  Sotianingsih Haryanto²  Samuel C. B. Stubbs³  Barbara A. Blacklaws³  Khin S. A. Myint¹  Simon D. W. Frost³  Marsha S. Santoso¹  Yanuarni W. B. Pamai⁶  Benediktus Yohan¹  Anna M. Afida⁷  Dionisius Denis¹  Ingrid A. Hutagalung⁸  Edison Johar¹  Rahma F. Hayati¹ 

[1] Eijkman Institute for Molecular Biology;Siloam Hospitals;Department of Veterinary Medicine, University of Cambridge, United Kingdom;Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, United Kingdom;Microsoft Research, United States;Santa Elisabeth Hospital;Dr. H. M. Ansari Saleh Hospital;Dr. M. Haulussy Hospital

关键词: arbovirus;    dengue;    serotypes;    chikungunya;    clinical;    Indonesia;   

DOI  :  10.3389/fmed.2020.582235

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The people of Indonesia have been afflicted by dengue, a mosquito-borne viral disease, for over 5 decades. The country is the world's largest archipelago with diverse geographic, climatic, and demographic conditions that may impact the dynamics of disease transmissions. A dengue epidemiology study was launched by us to compare and understand the dynamics of dengue and other arboviral diseases in three cities representing western, central, and eastern Indonesia, namely, Batam, Banjarmasin, and Ambon, respectively. A total of 732 febrile patients were recruited with dengue-like illness during September 2017–2019 and an analysis of their demographic, clinical, and virological features was performed. The seasonal patterns of dengue-like illness were found to be different in the three regions. Among all patients, 271 (37.0%) were virologically confirmed dengue, while 152 (20.8%) patients were diagnosed with probable dengue, giving a total number of 423 (57.8%) dengue patients. Patients' age and clinical manifestations also differed between cities. Mostly, mild dengue fever was observed in Batam, while more severe cases were prominent in Ambon. While all dengue virus (DENV) serotypes were detected, distinct serotypes dominated in different locations: DENV-1 in Batam and Ambon, and DENV-3 in Banjarmasin. We also assessed the diagnostic features in the study sites, which revealed different patterns of diagnostic agreements, particularly in Ambon. To detect the possibility of infection with other arboviruses, further testing on 461 DENV RT-PCR-negative samples was performed using pan-flavivirus and -alphavirus RT-PCRs; however, only one chikungunya infection was detected in Ambon. A diverse dengue epidemiology in western, central, and eastern Indonesia was observed, which is likely to be influenced by local geographic, climatic, and demographic conditions, as well as differences in the quality of healthcare providers and facilities. Our study adds a new understanding on dengue epidemiology in Indonesia.

【 授权许可】

CC BY