Trabecular Bone Score and Bone Quality in Systemic Lupus Erythematosus Patients

Frontiers in Medicine

article

Barbara Ruaro¹  Andrea Casabella²  Sabrina Paolino²  Elisa Alessandri²  Massimo Patané²  Emanuele Gotelli²  Alberto Sulli²  Maurizio Cutolo² 

[1] Pulmonology Department, University Hospital of Trieste;Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine (Di.M.I.), IRCCS San Martino Polyclinic Hospital, University of Genova;Bone and Joint Disease Research Center, Department of Internal Medicine Di.M.I., University of Genoa;Lupus Clinic, Department of Internal Medicine (Di.M.I.), IRCCS San Martino Polyclinic Hospital, University of Genova

关键词: osteoporosis;    trabecular bone score (TBS);    bone mineral density (BMD);    autoimmune diseases (AD);    bone loss;   

DOI  :  10.3389/fmed.2020.574842

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Systemic lupus erythematosus (SLE) patients run a higher risk of having low bone mass due to multifactorial events that include physical inactivity, persistent inflammation, low vitamin D levels, and glucocorticoid treatment. This study aimed at obtaining a comparison between bone involvement in SLE patients and healthy matched subjects (HS). Methods: A total of 40 SLE females (average age 54.1 ± 16.3 years) and 40 age–gender matched HS (average age 54.2 ± 15.9 years) were enrolled after having obtained informed written consent. Bone mineral density (BMD, g/cm 2 ) of the lumbar spine (L1–L4) was analyzed by a dual-energy X-ray absorptiometry (DXA) scan (GE, Lunar Prodigy). The lumbar spine trabecular bone score (TBS) was derived for each spine DXA examination by the TBS index (TBS iNsight Medimaps). Results: The lumbar spine TBS score was statistically significantly lower in SLE patients than in HS (0.797 ± 0.825 vs. 1.398 ± 0.207, p < 0.001, as was BMD ( p < 0.001) in all areas examined. Conclusions: SLE is associated with significant low bone mass as evidenced by DXA and TBS. This study emphasizes the importance of using DXA and TBS in the evaluation of the different aspects of bone architecture.

【 授权许可】

CC BY