Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study

Frontiers in Medicine

article

Man Li¹  Wei Long¹  Wei Zhou¹  Danyang Chen¹  Lin Zhou¹  Min Wang¹  Haibo Xu²  Aiping Deng³  Zeming Liu¹  Liang Guo¹  Biao Cheng³  Wen Zeng⁴  Sichao Chen¹  Mengqi Tu²  Meng Wu⁵  Wei Tong⁶  Shipei Wang¹  Yihui Huang¹ 

[1] Department of Plastic Surgery, Zhongnan Hospital of Wuhan University;Department of Radiology, Zhongnan Hospital of Wuhan University;Department of Pharmacy, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology;Department of Ophthalmology, Zhongnan Hospital of Wuhan University;Department of Ultrasound, Zhongnan Hospital of Wuhan University;Department of Orthopedics, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology

关键词: COVID-19;    mortality;    risk factors;    SARS-CoV-2;    Wuhan;   

DOI  :  10.3389/fmed.2020.00545

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objectives: An outbreak of coronavirus disease (COVID-19) in 2019 in Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial. Methods: A total of 245 adult patients with laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square, Fisher's exact, and the Mann-Whitney U -tests were used to compare the clinical characteristics between the survivors and non-survivors. To explore the risk factors associated with in-hospital death, univariable and multivariable cox regression analyses were used. Results: Of the 245 patients included in this study, 23 (9.4%) died in the hospital. The multivariate regression analysis showed increased odds of in-hospital deaths associated with age, D-dimer levels >1,000 ng/L, platelet count <125, and higher serum creatinine levels. Conclusions: We identified risk factors that show significant association with mortality in adult COVID-19 patients, and our findings provide valuable references for clinicians to identify high-risk patients with COVID-19 at an early stage.

【 授权许可】

CC BY