Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results

Frontiers in Medicine

article

Satoshi Nagase¹  Hiroyuki Sakakibara²  Akihiro Yoshida³  Akinori Hara⁴  Hiroyuki Nakamura⁴  Yoshiyu Takeda⁵  Hidetaka Nambo⁶  Takashi Yoneda⁵  Shigefumi Okamoto¹  Shigehiro Karashima⁵  Hiromasa Tsujiguchi⁴  Hirohito Tsuboi⁸  Sakae Miyagi⁴  Mitsuhiro Kometani⁵  Daisuke Aono⁵  Takuya Higashitani⁵  Masashi Demura⁹ 

[1] Department of Laboratory Science, Faculty of Health Sciences, Kanazawa University;Graduate School of Agriculture, University of Miyazaki;Department of Oral Microbiology, Matsumoto Dental University Graduate School of Oral Medicine;Department of Environmental and Preventive Medicine, Advanced Preventive Medical Sciences, Kanazawa University;Department of Endocrinology and Metabolism, Kanazawa University Hospital;School of Electrical, and Communication Engineering, College of Science and Engineering, Kanazawa University;Department of Health Promotion and Medicine of the Future, Kanazawa University Graduate School of Medicine;Division of Psychosomatic Medicine, Institute of Medical, and Health Sciences, Kanazawa University;Department of Hygiene, Kanazawa University Graduate School of Medicine

关键词: gut microbiome;    blood pressure;    salt-intake;    renin-angiotensin-aldosterone system;    hypertension;   

DOI  :  10.3389/fmed.2020.00475

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Salt intake is one of the most important environmental factors impacting hypertension onset. Meanwhile, the potential roles of the gut microbiome (GM) in altering the health status of hosts have drawn considerable attention. Here, we aimed to perform an observational study to investigate the impact of intestinal bacterial flora in hypertensive patients with low-salt or high-salt intake. A total of 239 participants were enrolled, and their gut microbiomes, clinical and demographic details, as well as physiological parameters pertaining to the renin-angiotensin-aldosterone system and inflammatory cytokine profiles, were examined. The participants were classified into four groups based on the presence of different enterotype bacteria, as determined via cluster analysis, and salt intake: low salt/GM enterotype 1, low salt/GM enterotype 2, high salt/GM enterotype 1, and high salt/GM enterotype 2. Results show that the prevalence of hypertension was significantly lower in the low-salt/GM enterotype 2 group (27%) compared to the low salt/GM enterotype 1 group (47%; p = 0.04). Alternatively, no significant differences were observed in hypertension prevalence between the two high-salt intake groups (GM enterotype 1 = 50%, GM enterotype 2 = 47%; p = 0.83). Furthermore, The low-salt/GM enterotype 2 was higher in the relative abundances of Blautia, Bifidobacterium, Escherichia-Shigella, Lachnoclostridium , and Clostridium sensu stricto than the low-salt/GM enterotype 1. differed significantly between the GM enterotypes. These results suggested that consumption of a low-salt diet was ineffective in regulating hypertension in individuals with a specific gut bacteria composition. Our findings support the restoration of GM homeostasis as a new strategy for controlling blood pressure and preventing the development of hypertension.

【 授权许可】

CC BY