Prealbumin as a Predictor of Prognosis in Patients With Coronavirus Disease 2019

Frontiers in Medicine

article

Ying Luo¹  Ying Xue²  Liyan Mao¹  Xu Yuan¹  Qun Lin¹  Guoxing Tang¹  Huijuan Song¹  Feng Wang¹  Ziyong Sun¹ 

[1] Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology;Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology

关键词: coronavirus disease 2019;    severe acute respiratory syndrome coronavirus 2;    prealbumin;    routine laboratory tests;    prognosis;    immune status;    fatal patients;    recovered patients;   

DOI  :  10.3389/fmed.2020.00374

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: The predictive value of prealbumin for the prognosis of coronavirus disease 2019 (COVID-19) has not been extensively investigated. Methods: A total of 1,115 patients with laboratory-confirmed COVID-19 were enrolled at Tongji hospital from February to April 2020 and classified into fatal ( n = 129) and recovered ( n = 986) groups according to the patient's outcome. Prealbumin and other routine laboratory indicators were measured simultaneously. Results: The level of prealbumin on admission was significantly lower in fatal patients than in recovered patients. For predicting the prognosis of COVID-19, the performance of prealbumin was better than most routine laboratory indicators, such as albumin, lymphocyte count, neutrophil count, hypersensitive C-reactive protein, d-dimer, lactate dehydrogenase, creatinine, and hypersensitive cardiac troponin I. When a threshold of 126 mg/L was used to discriminate between fatal and recovered patients, the sensitivity and specificity of prealbumin were, respectively, 78.29 and 90.06%. Furthermore, a model based on the combination of nine indexes showed an improved performance in predicting the death of patients with COVID-19. Using a cut-off value of 0.19, the prediction model was able to distinguish between fatal and recovered individuals with a sensitivity of 86.82% and a specificity of 90.37%. Conclusions: A lower level of prealbumin on admission may indicate a worse outcome of COVID-19. Immune and nutritional status may be vital factors for predicting disease progression in the early stage of COVID-19.

【 授权许可】

CC BY