Medium Term Follow-Up of 337 Patients With Coronavirus Disease 2019 (COVID-19) in a Fangcang Shelter Hospital in Wuhan, China

Frontiers in Medicine

article

Nao Yan¹  Wei Wang²  Yongzhe Gao¹  Junhui Zhou⁴  Jiuhong Ye³  Zhipeng Xu¹  Jing Cao¹  Junjian Zhang¹ 

[1] Department of Neurology, Zhongnan Hospital of Wuhan University;Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University;Wuhan East-West Lake Fangcang Shelter Hospital;Department of Nursing, Zhongnan Hospital of Wuhan University;Department of Medical Service, Zhongnan Hospital of Wuhan University

关键词: COVID-19;    nucleic acid;    re-positive;    post-discharge quarantine;    discharge surveillance;   

DOI  :  10.3389/fmed.2020.00373

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: With the adoption of powerful preventive and therapeutic measures, a large number of patients with COVID-19 have recovered and been discharged from hospitals in Wuhan, China. Prevention of epidemic rebound is a top priority of current works. However, information regarding post-discharge quarantine and surveillance of recovered patients with COVID-19 is scarce. Methods: This study followed up 337 patients with COVID-19 in a Wuhan East-West Lake Fangcang shelter hospital during the post-discharge quarantine. Demographic, clinical characteristics, comorbidities, and chest computed tomography (CT) image, mental state, medication status, and nucleic acid test data were summarized and analyzed. Results: 21/337 (6.2%) patients were SARS-CoV-2 nucleic acid re-positive, and 4 /337(1.2%) patients were suspected positive. The median day interval between the discharge to nucleic acid re-positivity was 7.5 days (IQR, 6–13), ranging from 6 to 13 days. Cough/expectoration are the most common symptoms, followed by chest congestion/dyspnea during the 2 weeks post-discharge quarantine. Risk factors of nucleic acid re-positivity including the number of lobes infiltration (odds ratio[OR], 1.14; 95% CI, 1.09–1.19), distribution (OR, 0.16; 95% CI, 0.13–0.19), CT imaging feature of patchy shadowing accompanying with consolidation (OR, 9.36; 95% CI, 7.84–11.17), respiratory symptoms of cough accompanying with expectoration (OR, 1.39; 95% CI, 1.28–1.52), and chest congestion accompanying by dyspnea (OR, 1.42; 95% CI, 1.28–1.57). Conclusion: The 2 weeks post-discharge quarantine may be an effective measure to prevent the outbreak from rebounding from the recovered patients. The second week is a critical period during post-discharge quarantine. Special attention should be paid to cough, expectoration, chest congestion, and dyspnea in recovered COVID-19 patients. A few recovered patients may prolong the quarantine based on clinical symptoms and signs and nucleic acid results in the 2 weeks of medical observation.

【 授权许可】

CC BY