Alcohol? Not for Non-alcoholic Fatty Liver Disease Patients

Frontiers in Medicine

article

Francesca Cainelli¹  Titya Thao²  Carolyne Pung¹  Sandro Vento² 

[1] Raffles Medical Group Clinic;Faculty of Medicine, University of Puthisastra

关键词: non-alcoholic fatty liver disease;    non-alcoholic steatohepatitis;    liver fibrosis;    alcohol;    liver cirrhosis;    hepatocellular carcinoma;   

DOI  :  10.3389/fmed.2020.00014

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide, with an estimated global prevalence of 25%, liver-specific mortality of 0.77 persons per 1,000, and overall mortality of 11.77 per 1,000 person-years (1). It has long been debated whether alcohol consumption influences the course of NAFLD. Three of the most recent studies have shed light over this important issue. In a study conducted in the United States, alcohol consumption of at least 30 g/day for men and 15 g/day for women was associated with increased mortality in individuals with fatty liver and metabolic syndrome (2). In a Finnish study, even low alcohol intake in fatty liver disease was associated with increased risks for advanced liver disease and cancer (3). Finally, in a South Korean study, even though low alcohol consumption was linked to a decreased risk of incident hepatic steatosis, the same levels of low alcohol consumption were associated with a higher risk of developing advanced liver fibrosis in those subjects who progressed to more severe NAFLD over time (4).

【 授权许可】

CC BY