Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications

Frontiers in Medicine

article

Javier Donate-Correa¹  Carla M. Ferri¹  Fátima Sánchez-Quintana¹  Atteneri Pérez-Castro¹  Ainhoa González-Luis¹  Ernesto Martín-Núñez¹  Carmen Mora-Fernández¹  Juan F. Navarro-González¹ 

[1] Hospital Universitario Nuestra Señora de Candelaria;GEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética), Sociedad Española de Nefrología;Doctoral and Graduate School, University of La Laguna;Instituto de Salud Carlos III;Instituto de Tecnologías Biomédicas, Universidad de La Laguna

关键词: diabetic kidney disease;    inflammation;    inflammatory cytokines;    SGLT2i;    GLP-1RA;    DPP-4i;    pentoxifylline;   

DOI  :  10.3389/fmed.2020.628289

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and a main contributing factor for cardiovascular morbidity and mortality in patients with diabetes mellitus. Strategies employed to delay the progression of this pathology focus on the control of traditional risk factors, such as hyperglycemia, and elevated blood pressure. Although the intimate mechanisms involved in the onset and progression of DKD remain incompletely understood, inflammation is currently recognized as one of the main underlying processes. Untangling the mechanisms involved in the appearing of a harmful inflammatory response in the diabetic patient is crucial for the development of new therapeutic strategies. In this review, we focus on the inflammation-related pathogenic mechanisms involved in DKD and in the therapeutic utility of new anti-inflammatory strategies.

【 授权许可】

CC BY