Targeting the GRP78 Pathway for Cancer Therapy

Frontiers in Medicine

article

Guanhua Lu¹  Hui Luo²  Xiao Zhu¹ 

[1] Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University;The Marine Biomedical Research Institute of Guangdong Zhanjiang;Southern Marine Science and Engineering Guangdong Laboratory;The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University

关键词: GRP78;    endoplasmic reticulum stress;    autophagy;    apoptosis;    tumor-targeted therapy;   

DOI  :  10.3389/fmed.2020.00351

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The 78-kDa glucose-regulated protein (GRP78) plays an important part in maintaining protein stability, regulating protein folding, and inducing apoptosis autophagy, which is considered as a powerful protein. Meanwhile, it also plays a role in ensuring the normal function of organs. In recent years, more and more researches have been carried out on the targeted therapy of GRP78, mainly focusing on its relevant role in tumor and its role as a major modulator and modulator of subordinate pathways. The ability of GRP78 to respond to endoplasmic reticulum stress (ERS) determines whether tumor cells survive and whether the changes in expression level of GRP78 regulated by endoplasmic reticulum (ER) caused by various factors will directly or indirectly affect cell proliferation, apoptosis, and injury, or reduce the body's defense ability, or have protective effects on various organs.

【 授权许可】

CC BY