Extracellular Vesicles as Mediators of Cellular Cross Talk in the Lung Microenvironment

Frontiers in Medicine

article

Sabine Bartel¹  Jessy Deshane²  Tom Wilkinson³  Susanne Gabrielsson⁴ 

[1] Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen;Pulmonary Allergy and Critical Care Medicine, University of Alabama at Birmingham, United States;Clinical and Experimental Science, Faculty of Medicine, University of Southampton, United Kingdom;Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute;Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital

关键词: extracellular vesicles;    exosomes;    asthma;    chronic obstructive pulmonary disease;    sarcoidosis;    microRNA;   

DOI  :  10.3389/fmed.2020.00326

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The human lung is a complex tissue subdivided into several regions that differ in size, function, and resident cell types. Despite years of intensive research, we still do not fully understand the cross talk between these different regions and diverse cell populations in the lung and how this is altered in the development of chronic respiratory disease. The discovery of extracellular vesicles (EVs), small membrane vesicles released from cells for intercellular communication, has added another layer of complexity to cellular cross talk in the complex lung microenvironment. EVs from patients with chronic obstructive pulmonary disease, asthma, or sarcoidosis have been shown to carry microRNAs, proteins, and lipids that may contribute to inflammation or tissue degeneration. Here, we summarize the contribution of these small vesicles in the interplay of several different cell types in the lung microenvironment, with a focus on the development of chronic respiratory diseases. Although there are already many studies demonstrating the adverse effects of EVs in the diseased lung, we still have substantial knowledge gaps regarding the concrete role of EV involvement in lung disease, which should be addressed in future studies.

【 授权许可】

CC BY