Dexmedetomidine Combined With Butorphanol or Sufentanil for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Microvascular Decompression: A Randomized Controlled Trial

Frontiers in Medicine

article

Guangjun Xu¹  Jing Zhao¹  Zunyuan Liu¹  Guoying Liu¹  Lei Liu¹  Chunguang Ren¹  Yanchao Liu¹ 

[1] Department of Anaesthesiology, Liaocheng People's Hospital

关键词: post-operative nausea and vomiting;    microvascular decompression;    butorphanol;    sufentanil;    dexmedetomidine;   

DOI  :  10.3389/fmed.2020.583031

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Patients undergoing microvascular decompression are often accompanied with high risk of post-operative nausea and vomiting (PONV). In this study, we compare the antiemetic efficacy of butorphanol or sufentanil combined with dexmedetomidine in patients undergoing microvascular decompression. Methods: Patients undergoing microvascular decompression were randomized into two groups. The primary outcome was the occurrence and severity of PONV during the 72 h after surgery. Secondary outcomes included levels of pain intensity and sedation and consumption of opioids at 1, 2, 6, 12, 24, 48, and 72 h after surgery. We also recorded the intraoperative hemodynamics, consumption of narcotic drugs, operation and anesthesia time, estimated blood loss, infusion volume and urine output, requirements of rescue antiemetics or analgesics, the satisfaction scores of patients and surgeons, complications, and length of stay. Results: The overall incidence rates of nausea and vomiting during the 72 h after surgery were significantly reduced in group DB (76.00 and 44.00% in group DS vs. 54.17% and 22.92% in group DB, P 0.05). The consumption of opioid morphine equivalent was significantly reduced in group DB ( P < 0.05). Compared with those in group DS, the satisfaction scores of both patients and surgeons were significantly increased in group DB ( P < 0.05). Conclusion: Butorphanol combined with dexmedetomidine could reduce early PONV and the number of patients requiring rescue antiemetics, especially at intervals of 1–6 h, while the satisfaction scores of both patients and surgeons were significantly increased.

【 授权许可】

CC BY