68 Ga-DOTATOC PET/CT-Based Radiomic Analysis and PRRT Outcome: A Preliminary Evaluation Based on an Exploratory Radiomic Analysis on Two Patients

Frontiers in Medicine

article

Virginia Liberini¹  Federica Fioroni²  Annibale Versari³  Filippo Molinari⁴  Désirée Deandreis¹  Osvaldo Rampado⁵  Elena Gallio⁵  Bruno De Santi⁴  Francesco Ceci¹  Beatrice Dionisi¹  Philippe Thuillier¹  Libero Ciuffreda⁷  Alessandro Piovesan⁸ 

[1] Nuclear Medicine Unit, Department of Medical Sciences, University of Turin;Medical Physics Unit, Azienda Unit Sanitaria Locale di Reggio Emilia - Istituto di Ricovero e Cura a Carattere Scientifico of Reggio Emilia;Nuclear Medicine Unit, Azienda Unit Sanitaria Locale di Reggio Emilia - Istituto di Ricovero e Cura a Carattere Scientifico of Reggio Emilia;Department of Electronics and Telecommunications;Medical Physics Unit, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza;Department of Endocrinology, University Hospital of Brest;Medical Oncology Division 1, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, University of Turin;Division of Oncological Endocrinology, Department of Medical Sciences, University of Turin

关键词: 68 Ga-DOTATOC PET/CT;    peptide receptor radionuclide therapy;    radiomic analysis;    NET;    total lesion somatostatin receptor expression;    somatostatin receptor expressing tumor volume;   

DOI  :  10.3389/fmed.2020.601853

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Aim: This work aims to evaluate whether the radiomic features extracted by 68Ga-DOTATOC-PET/CT of two patients are associated with the response to peptide receptor radionuclide therapy (PRRT) in patients affected by neuroendocrine tumor (NET). Methods: This is a pilot report in two NET patients who experienced a discordant response to PRRT (responder vs. non-responder) according to RECIST1.1. The patients presented with liver metastasis from the rectum and pancreas G3-NET, respectively. Whole-body total-lesion somatostatin receptor-expression (TLSREwb-50) and somatostatin receptor-expressing tumor volume (SRETV wb-50) were obtained in pre- and post-PRRT PET/CT. Radiomic analysis was performed, extracting 38 radiomic features (RFs) from the patients' lesions. The Mann–Whitney test was used to compare RFs in the responder patient vs. the non-responder patient. Pearson correlation and principal component analysis (PCA) were used to evaluate the correlation and independence of the different RFs. Results: TLSREwb-50 and SRETVwb-50 modifications correlate with RECIST1.1 response. A total of 28 RFs extracted on pre-therapy PET/CT showed significant differences between the two patients in the Mann–Whitney test ( p < 0.05). A total of seven second-order features, with poor correlation with SUVmax and PET volume, were identified by the Pearson correlation matrix. Finally, the first two PCA principal components explain 83.8% of total variance. Conclusion: TLSREwb-50 and SRETVwb-50 are parameters that might be used to predict and to assess the PET response to PRRT. RFs might have a role in defining inter-patient heterogeneity and in the prediction of therapy response. It is important to implement future studies with larger and more homogeneous patient populations to confirm the efficacy of these biomarkers.

【 授权许可】

CC BY