COVID-19 Induced Acute Respiratory Distress Syndrome—A Multicenter Observational Study

Frontiers in Medicine

article

Johannes Herrmann¹  Iuliu Torje²  Benedikt Schmid¹  Tobias Schlesinger¹  Caroline Rolfes²  Christian Reyher²  Markus Kredel¹  Jan Stumpner¹  Alexander Brack¹  Thomas Wurmb¹  Daniel Gill-Schuster¹  Elisabeth Hannah Adam³  Peter Kranke¹  Dirk Weismann⁴  Hartwig Klinker⁵  Peter Heuschmann⁶  Viktoria Rücker⁶  Stefan Frantz⁴  Georg Ertl⁴  Ralf Michael Muellenbach²  Haitham Mutlak¹  Patrick Meybohm¹  Quirin Notz¹  Kai Zacharowski³  Christopher Lotz¹  Philipp Helmer³  Michael Sonntagbauer³  Peter Ungemach-Papenberg¹  Andreas Sanns¹  York Zausig¹  Thorsten Steinfeldt¹ 

[1] Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg;Department of Critical Care, Emergency Medicine and Anesthesiology, ARDS/ECMO-Centre, Campus Kassel of the University of Southampton;Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University;Department of Internal Medicine I, University Hospital Würzburg;Department of Internal Medicine II, University Hospital Würzburg;Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-University;Clinical Trial Center, University Hospital Würzburg, Julius-Maximilians-University

关键词: COVID-19;    ARDS (acute respiratory distress syndrome);    intensive care medicine;    pandemia;    Germany;   

DOI  :  10.3389/fmed.2020.599533

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included. Results: A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay. Conclusions: A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients.

【 授权许可】

CC BY