Juvenile Spondyloarthritis: What More Do We Know About HLA-B27, Enthesitis, and New Bone Formation?

Frontiers in Medicine

article

Shi Huan Tay¹  Joo Guan Yeo¹  Jing Yao Leong¹  Salvatore Albani¹  Thaschawee Arkachaisri² 

[1] SingHealth Duke-National University of Singapore Academic Medical Centre, Translational Immunology Institute;Duke-National University of Singapore Medical School;Department of Pediatric Subspecialties, KK Women's and Children's Hospital

关键词: juvenile arthritis;    spondyloarthritis;    enthesitis related arthritis;    HLA-B27;    osteogenesis;    enthesitis;   

DOI  :  10.3389/fmed.2021.666772

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Juvenile spondyloarthritis (JSpA) refers to a diverse spectrum of immune-mediated inflammatory arthritides whose onset occurs in late childhood and adolescence. Like its adult counterpart, JSpA is typified by a strong association with human leukocyte antigen-B27 (HLA-B27) and potential axial involvement, while lacking rheumatoid factor (RF) and distinguishing autoantibodies. A characteristic manifestation of JSpA is enthesitis (inflammation of insertion sites of tendons, ligaments, joint capsules or fascia to bone), which is commonly accompanied by bone resorption and new bone formation at affected sites. In this Review, advances in the role of HLA-B27, enthesitis and its associated osteoproliferation in JSpA pathophysiology and treatment options will be discussed. A deeper appreciation of how these elements contribute to the JSpA disease mechanism will better inform diagnosis, prognosis and therapy, which in turn translates to an improved quality of life for patients.

【 授权许可】

CC BY