Serum Troponin T Concentrations Are Frequently Elevated in Advanced Skin Cancer Patients Prior to Immune Checkpoint Inhibitor Therapy: Experience From a Single Tertiary Referral Center

Frontiers in Medicine

article

Jonas K. Kurzhals¹  Tobias Graf²  Katharina Boch¹  Ulrike Grzyska³  Alex Frydrychowicz³  Detlef Zillikens¹  Patrick Terheyden¹  Ewan A. Langan¹ 

[1] Department of Dermatology, University of Lübeck;Department of Cardiology, University of Lübeck;Department of Radiology and Nuclear Medicine, University of Lübeck;Dermatological Sciences, University of Manchester, United Kingdom

关键词: myocarditis;    immune checkpoint inhibition;    melanoma;    non-melanoma skin cancer;    troponin;   

DOI  :  10.3389/fmed.2021.691618

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of several human malignancies, particularly metastatic skin cancer. However, immune-related myocarditis (irM), an immune-mediated adverse event (irAE), is often fatal. In the absence of a reliable biomarker, measurement of pre-ICI therapy serum troponin concentration has been proposed to identify patients at risk of developing irM, although real-world studies examining this strategy are lacking. Thus, we retrospectively analyzed the case records of all patients who commenced ICI therapy between January 2018 and December 2019 in a single university skin cancer center ( n = 121) to (i) determine the incidence of irM, (ii) establish the frequency of pretreatment serum hsTnT elevations, and (iii) to establish whether this identified patients who subsequently developed irM. Only one patient developed irM, resulting in an overall incidence of 0.8%. Pretreatment hsTnT was measured in 47 patients and was elevated in 13 (28%). Elevated serum hsTnT concentrations were associated with chronic renal failure ( p = 0.02) and diabetes ( p < 0.0002). Pretreatment hsTnT was not elevated in the patient who developed fulminant irM. Pre-immunotherapy serum hsTnT concentrations were often asymptomatically elevated in patients with advanced skin cancer, none of whom subsequently developed irM during ICI therapy. However, large studies are required to assess the positive and negative predictive values of hsTnT for the development of irM. In the meantime, elevated hsTnT concentrations should be investigated before initiation of immunotherapy and closely monitored during early treatment cycles, where the risk of irM is greatest.

【 授权许可】

CC BY