Integrating Real-World Evidence in the Regulatory Decision-Making Process: A Systematic Analysis of Experiences in the US, EU, and China Using a Logic Model

Frontiers in Medicine

article

Meng Li¹  Zuanji Liang¹  Jiaqi Wang¹  Junnan Shi¹  Haojie Lin¹  Dongning Yao¹  Hao Hu¹  Carolina Oi Lam Ung¹ 

[1] State Key Laboratory in Quality Research of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau

关键词: regulatory science;    real-world evidence;    decision-making;    logic model;    regulation;   

DOI  :  10.3389/fmed.2021.669509

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Real world evidence (RWE) and real-world data (RWD) are drawing ever-increasing attention in the pharmaceutical industry and drug regulatory authorities (DRAs) all over the world due to their paramount role in supporting drug development and regulatory decision making. However, there is little systematic documentary analysis about how RWE was integrated for the use by the DRAs in evaluating new treatment approaches and monitoring post-market safety. This study aimed to analyze and discuss the integration of RWE into regulatory decision-making process from the perspective of DRAs. Different development strategies to develop and adopt RWE by the DRAs in the US, Europe, and China were reviewed and compared, and the challenges encountered were discussed. It was found that different strategies on development of RWE were applied by FDA, EMA, and NMPA. The extent to which RWE was adopted in China was relatively limited compared to that in the US and EU, which was highly related to the national pharmaceutical environment and development stages. A better understanding of the overall goals, inputs, activities, outputs, and outcomes in developing RWE will help inform actions to harness RWD and leverage RWE for better health care decisions.

【 授权许可】

CC BY