Regional Differences in Epidemiological and Clinical Characteristics, Treatment, and Clinical Outcomes of COVID-19 in Wuhan and Remote Areas of Hubei Province

Frontiers in Medicine

article

Honggang Ren¹  Guogang Xu²  Xingyi Guo³  Antonio Palazón-Bru⁴  Pengcheng Yang⁵  Nan Huo⁶  Runsheng Wang⁷  Yu Sun⁸  Qinyong Hu⁵  Hua Yang^1,10 

[1] Department of Internal Medicine, Tongji Medical College, Huazhong University of Science and Technology;The Second Medical Centre and National Clinical Research Centre for Geriatric Diseases, Chinese People's Liberation Army of China General Hospital;Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, United States;Department of Clinical Medicine, Miguel Hernández University of Elche;Renmin Hospital of Wuhan University;Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, United States;Second Medical Center, People's Liberation Army General Hospital;Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology;Cancer Centre, Renmin Hospital of Wuhan University;Department of Respiratory Medicine, Minzu University Hospital of Hubei Minzu University

关键词: SARS-CoV-2;    COVID-19;    regional differences;    mortality;    clinical characteristics;   

DOI  :  10.3389/fmed.2021.667623

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: The Coronavirus disease 2019 (COVID-19) pandemic has been a major threat to global health. Regional differences in epidemiological and clinical characteristics, treatment and outcomes of patients have not yet been investigated. This study was conducted to investigate these differences amongCOVID-19 patients in Hubei Province, China. Methods: This retrospective cross-sectional study analyzed data on 289 COVID-19 patients from designated hospitals in three regions:Urban (Wuhan Union West Hospital), Suburban areas of Wuhan (Hannan Hospital) and Enshi city, between February 8 and 20, 2020. The final date of follow-up was December 14th, 2020. The outcomes were case fatality rate and epidemiological and clinical data. Results: Urban Wuhan experienced a significantly higher case fatality rate (21.5%) than suburban Wuhan (5.23%) and rural area of Enshi (3.51%). Urban Wuhan had a higher proportion of patients on mechanical ventilation (24.05%) than suburban Wuhan (0%) and rural Enshi (3.57%). Treatment with glucocorticoids was equivalent in urban and suburban Wuhan (46.84 and 45.75%, respectively) and higher than Enshi (25.00%). Urban Wuhan had a higher proportion of patients with abnormal tests including liver function and serum electrolytes and a higher rate of pneumonia ( p < 0.01 for all). Urban Wuhan also had a higher incidence of respiratory failure, heart disease, liver disease and shock, compared with the other two regions (all p < 0.05). Conclusions: Our findings revealed that there are regional differences in COVID-19. These findings provide novel insights into the distribution of appropriate resources for the prevention, control and treatment of COVID-19 for the global community.

【 授权许可】

CC BY