Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score

Frontiers in Medicine

article

Yu-Feng Xiao¹  Cheng Zhang²  Wen-Jing Zhang²  Wei Duan²  Yong-Feng Tian²  Ping Li²  Hao Wu⁹  Cai-Ping Song²  En Liu¹  Shi-Ming Yang¹  Jia-Lin He¹  Yu Xu²  Xi Liu¹  Hui Lin¹  Qi Li²  Zhi Xu²  Ming-Dong Hu²  Xiao-Bao Ren² 

[1] Department of Gastroenterology, Xinqiao Hospital, The Army Medical University;Huo-Shen-Shan Hospital;The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital;Department of Hematology, Xinqiao Hospital, The Army Medical University;Department of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University;Department of Neurology, Xinqiao Hospital, The Army Medical University;Department of Endocrinology, Xinqiao Hospital, The Army Medical University;Department of Cardiology, Xinqiao Hospital, The Army Medical University;Taikang Tongji Hospital;Department of Emergency, Xinan Hospital, The Army Medical University

关键词: diabetes;    COVID-19;    severity;    mortality;    risk score;   

DOI  :  10.3389/fmed.2021.655604

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objectives: Diabetes is a risk factor for poor COVID-19 prognosis. The analysis of related prognostic factors in diabetic patients with COVID-19 would be helpful for further treatment of such patients. Methods: This retrospective study involved 3623 patients with COVID-19 (325 with diabetes). Clinical characteristics and laboratory tests were collected and compared between the diabetic group and the non-diabetic group. Binary logistic regression analysis was applied to explore risk factors associated in diabetic patients with COVID-19. A prediction model was built based on these risk factors. Results: The risk factors for higher mortality in diabetic patients with COVID-19 were dyspnea, lung disease, cardiovascular diseases, neutrophil, PLT count, and CKMB. Similarly, dyspnea, cardiovascular diseases, neutrophil, PLT count, and CKMB were risk factors related to the severity of diabetes with COVID-19. Based on these factors, a risk score was built to predict the severity of disease in diabetic patients with COVID-19. Patients with a score of 7 or higher had an odds ratio of 7.616. Conclusions: Dyspnea is a critical clinical manifestation that is closely related to the severity of disease in diabetic patients with COVID-19. Attention should also be paid to the neutrophil, PLT count and CKMB levels after admission.

【 授权许可】

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