Frequency of Systemic Lupus Erythematosus Was Decreasing Among Hospitalized Patients From 2013 to 2017 in a National Database in China

Frontiers in Medicine

article

Ying Tan¹  Feng Yu¹  Jianyan Long⁷  Lanxia Gan⁷  Haibo Wang⁷  Luxia Zhang¹  Minghui Zhao¹ 

[1] Renal Division, Department of Medicine, Peking University First Hospital;Peking University Institute of Nephrology;Key Laboratory of Renal Disease, Ministry of Health of China;Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China;Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences;Department of Nephrology, Peking University International Hospital;China Standard Medical Information Research Center;Center for Data Science in Health and Medicine, Peking University;Peking-Tsinghua Center for Life Sciences

关键词: systemic lupus erythaematosus;    lupus nephritis;    frequency;    hospitalized population;    mortality;   

DOI  :  10.3389/fmed.2021.648727

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Backgrounds: Limited data was reported for the frequency of SLE in China. The aim of this study was to investigate the frequency, geographical, and ethnic distributions of hospitalized SLE patients with data from the Hospital Quality Monitoring System (HQMS) in China. Methods: Hospitalized patients were investigated from a national inpatient database covering 46.0% of tertiary hospitals in China from 2013 to 2017. Data regarding the diagnosis of SLE were extracted based on ICD-10 codes. We collected and analyzed data from the front page of the records of inpatients, including frequency, demographic characteristics, and geographic distributions of SLE. Results: Among 158.3 million inpatients attended during the study period, 0.31% (491, 225) were diagnosed with SLE. The frequency of SLE decreased during the study period (from 0.30% in 2013 to 0.27% in 2017). The frequency of SLE increased with latitude (0.21% in northern China and 0.39% in southern China in 2017). Hospitalizations mostly occurred in winter (31.24%). The Li population had the highest frequency of patients with SLE (0.76%). The all-cause in-hospital mortality rate of SLE decreased from 0.74% (255/34,746) in 2013 to 0.54% (295/54,168) in 2017. The percentage of SLE patients with infections increased from 3.14% in 2013 to 4.72% in 2017. The percentage of SLE patients with tumors and thrombosis also increased slightly from 0.85 and 1.43% in 2013 to 1.27 and 2.45% in 2017, respectively. Conclusion: This study provided epidemiological information of SLE in hospitalized patients in China for the first time. An ethnic and spatial clustering trend of SLE was observed.

【 授权许可】

CC BY