Early Life Microbial Exposure and Immunity Training Effects on Asthma Development and Progression

Frontiers in Medicine

article

Andressa Daronco Cereta¹  Luis Vicente Franco de Oliveira²  Renata Kelly da Palma¹  Vinícius Rosa Oliveira³  Ivan Peres Costa⁶  Letícia Lopes Guimarães¹  João Pedro Ribeiro Afonso²  Adriano Luís Fonseca²  Alan Robson Trigueiro de Sousa²  Guilherme Augusto Moreira Silva²  Diego A. C. P. G. Mello² 

[1] School of Veterinary Medicine and Animal Sciences, University of São Paulo;Post Graduation Program Medical School, University Center of Anápolis-UniEVANGELICA;Department of Physical Therapy, EUSES University School, University of Barcelona-University of Girona (UB-UdG);Institute for Bioengineering of Catalonia;Research Group on Methodology, Models and Outcomes of Health and Social Sciences (M 3 O), University of VIC-Central University of Catalonia;Master's and Doctoral Programs in Rehabilitation Sciences, Nove de Julho University

关键词: asthma;    lung microbiome;    dysbiosis;    early life immunity;    prevention strategies;   

DOI  :  10.3389/fmed.2021.662262

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Asthma is the most common inflammatory disease affecting the lungs, which can be caused by intrauterine or postnatal insults depending on the exposure to environmental factors. During early life, the exposure to different risk factors can influence the microbiome leading to undesired changes to the immune system. The modulations of the immunity, caused by dysbiosis during development, can increase the susceptibility to allergic diseases. On the other hand, immune training approaches during pregnancy can prevent allergic inflammatory diseases of the airways. In this review, we focus on evidence of risk factors in early life that can alter the development of lung immunity associated with dysbiosis, that leads to asthma and affect childhood and adult life. Furthermore, we discuss new ideas for potential prevention strategies that can be applied during pregnancy and postnatal period.

【 授权许可】

CC BY