Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting

Frontiers in Medicine

article

Dario Monzani¹  Kristiaan Nackaerts³  Marie Vandevelde³  Evelyne Louis³  Herbert Decaluwé⁴  Paul De Leyn⁴  Hanne Declerck⁴  Eva G. Katz⁵  Francesco Petrella⁶  Monica Casiraghi⁶  Ilaria Durosini¹  Serena Petrocchi¹  Giulia Galli⁷  Marina Chiara Garassino⁸  G. Ardine de Wit⁹  Gabriella Pravettoni¹  Isabelle Huys^1,10  Serena Oliveri¹  Jorien Veldwijk^1,11  Rosanne Janssens^1,10  Luca Bailo¹  Meredith Y. Smith^1,13  Ian Smith⁹  Elise Schoefs^1,10 

[1] Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology IRCCS;Department of Oncology and Hemato-Oncology, University of Milan;Department of Respiratory Oncology, University Hospital Leuven;Department of Thoracic Surgery;Janssen Research and Development, United States;Thoracic Surgery Division, European Institute of Oncology IRCCS;Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori;University of Chicago Department of Medicine Section Hematology/Oncology, United States;Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University;Department of Pharmaceutical and Pharmacological Sciences;Erasmus Choice Modelling Centre, Erasmus University Rotterdam;Erasmus School of Health Policy & Management, Erasmus University Rotterdam;Inc., United States;University of Southern California School of Pharmacy, United States

关键词: non-small cell lung cancer;    patient preference;    discrete choice experiment;    swing weighting;    educational tool;    health literacy;    health locus of control;    quality of life;   

DOI  :  10.3389/fmed.2021.689114

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit–risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients. Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool. Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perform against each other in eliciting patient preferences. Overall, this protocol may assist researchers, drug developers, and decision-makers in designing quantitative patient preferences into decision-making along the medical product life cycle.

【 授权许可】

CC BY